Consult a health care practitioner prior to use if you are taking blood thinners, cholesterol lowering medication or EPA in fish oils, have a blood clotting disorder, have diabetes, gallstones or other biliary disorders. Consult a health care practitioner if heartburn, flatulence, or gastrointestinal irritations persist or if symptoms persist or worsen. Consult a health care practitioner prior to use with other drugs, herbs or medications, including protease inhibitors, anti-coagulants, or acetaminophen. Exercise caution if operating heavy machinery, driving a motor vehicle, or involved in activities requiring mental alertness. Discontinue use if skin hypersensitivity occurs (such as skin or mucous membrane irritation). Do not use if you have stomach hyperacidity, gastric or duodenal ulcers, pemphigus, fever or febrile disorder, seizure disorder, bile duct obstruction, cholangitis, liver disease or impaired liver function. Do not use if you are allergic to members of the Asteraceae/Compositae family. Hypersensitivity, such as allergy, has been known to occur; in which case discontinue use. Do not use if pregnant, breastfeeding, or prior to surgery. Keep out of reach of children. Do not exceed recommended dose.